Towards understanding the neural underpinnings of associative memory: A tES-EEG study
2023
Аутори
Paunović, DunjaBjekić, Jovana
Vulić, Katarina
Živanović, Marko
Konstantinović, Uroš
Stanković, Marija
Filipović, Saša R.
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Associative memory (AM) represents an ability to bind unrelated information into meaningful units and encode them as distinct memories. AM has been the function of interest in many non-invasive transcranial electrical stimulation (tES) studies aiming to maximize the potential for memory modulation by varying stimulation loci, frequency, and amplitude. In the current study, we aimed to capture the tES modulation potential of AM performance when tailoring the stimulation protocols to the individual brain rhythms. By matching the stimulation frequency to the frequency of each subject’s AM task-induced electrophysiological (EEG) activity in theta spectrum (4-8 Hz), we developed two types of personalized oscillatory protocols: theta-modulated otDCS and transcranial alternating current stimulation (tACS), which we administered alongside the constant transcranial direct current stimulation (tDCS) and a sham condition in the single-blind cross-over experiment. To comparatively assess the effe...cts of different tES protocols delivered over the posterior parietal cortex, we tested the recognition and recall ability of the 42 healthy young adults on paired associate paradigms after each of four conditions. During AM assessment participant’s EEG activity was recorded. Group-level comparisons of each active tES condition against sham did not show differences in AM task performance either on recognition or cued-recall. However, data showed variability in performance depending on the task and the outcome measures. To explore the potential sources of variability in effect expression, analysis of the function-relevant neurophysiological markers is necessary. Therefore, behavioral results will be accompanied by features of underlying brain activity extracted from the EEG signals. Apart from introducing a novel approach to probing AM with personalized tES, this well-powered, multi-protocol, multi-task, and multi-measure study produced a comprehensive dataset that allows exploration of factors that could uncover different patterns in responsiveness to tES, as well as the insight into how neurophysiological changes reflected on the behavioral level.
Кључне речи:
associative memory / transcranial electrical stimulation (tes) / electroencephalography (eeg)Извор:
IBRO 11th World Congress of Neuroscience Supplement 1, 2023, 879-Издавач:
- Elsevier
Финансирање / пројекти:
- Horizon Europe – project TWINNIBS "Twinning for excellence in non-invasive brain stimulation in Western Balkans” (grant no. 101059369)
- Ministry of Science, Technological Development, and Innovations of the Republic of Serbia (University of Belgrade, Institute for Medical Research - grant no. 451-03-47/2023-01/200015)
- Ministry of Science, Technological Development, and Innovations of the Republic of Serbia (University of Belgrade, Faculty of Philosophy - grant no. 451-03-47/2023-01/200163)
Напомена:
- IBRO 2023 - 11th IBRO World Congress of Neuroscience (9-13 September, Granada, Spain)
ISSN: 2667-2421; 2667-2421; 2667-2421; 2667-2421; 2667-2421; 2667-2421; 2667-2421; 2667-2421
[ Google Scholar ]Институција/група
Psihologija / PsychologyTY - CONF AU - Paunović, Dunja AU - Bjekić, Jovana AU - Vulić, Katarina AU - Živanović, Marko AU - Konstantinović, Uroš AU - Stanković, Marija AU - Filipović, Saša R. PY - 2023 UR - http://reff.f.bg.ac.rs/handle/123456789/4887 AB - Associative memory (AM) represents an ability to bind unrelated information into meaningful units and encode them as distinct memories. AM has been the function of interest in many non-invasive transcranial electrical stimulation (tES) studies aiming to maximize the potential for memory modulation by varying stimulation loci, frequency, and amplitude. In the current study, we aimed to capture the tES modulation potential of AM performance when tailoring the stimulation protocols to the individual brain rhythms. By matching the stimulation frequency to the frequency of each subject’s AM task-induced electrophysiological (EEG) activity in theta spectrum (4-8 Hz), we developed two types of personalized oscillatory protocols: theta-modulated otDCS and transcranial alternating current stimulation (tACS), which we administered alongside the constant transcranial direct current stimulation (tDCS) and a sham condition in the single-blind cross-over experiment. To comparatively assess the effects of different tES protocols delivered over the posterior parietal cortex, we tested the recognition and recall ability of the 42 healthy young adults on paired associate paradigms after each of four conditions. During AM assessment participant’s EEG activity was recorded. Group-level comparisons of each active tES condition against sham did not show differences in AM task performance either on recognition or cued-recall. However, data showed variability in performance depending on the task and the outcome measures. To explore the potential sources of variability in effect expression, analysis of the function-relevant neurophysiological markers is necessary. Therefore, behavioral results will be accompanied by features of underlying brain activity extracted from the EEG signals. Apart from introducing a novel approach to probing AM with personalized tES, this well-powered, multi-protocol, multi-task, and multi-measure study produced a comprehensive dataset that allows exploration of factors that could uncover different patterns in responsiveness to tES, as well as the insight into how neurophysiological changes reflected on the behavioral level. PB - Elsevier C3 - IBRO 11th World Congress of Neuroscience Supplement 1 T1 - Towards understanding the neural underpinnings of associative memory: A tES-EEG study SP - 879 UR - https://hdl.handle.net/21.15107/rcub_reff_4887 ER -
@conference{ author = "Paunović, Dunja and Bjekić, Jovana and Vulić, Katarina and Živanović, Marko and Konstantinović, Uroš and Stanković, Marija and Filipović, Saša R.", year = "2023", abstract = "Associative memory (AM) represents an ability to bind unrelated information into meaningful units and encode them as distinct memories. AM has been the function of interest in many non-invasive transcranial electrical stimulation (tES) studies aiming to maximize the potential for memory modulation by varying stimulation loci, frequency, and amplitude. In the current study, we aimed to capture the tES modulation potential of AM performance when tailoring the stimulation protocols to the individual brain rhythms. By matching the stimulation frequency to the frequency of each subject’s AM task-induced electrophysiological (EEG) activity in theta spectrum (4-8 Hz), we developed two types of personalized oscillatory protocols: theta-modulated otDCS and transcranial alternating current stimulation (tACS), which we administered alongside the constant transcranial direct current stimulation (tDCS) and a sham condition in the single-blind cross-over experiment. To comparatively assess the effects of different tES protocols delivered over the posterior parietal cortex, we tested the recognition and recall ability of the 42 healthy young adults on paired associate paradigms after each of four conditions. During AM assessment participant’s EEG activity was recorded. Group-level comparisons of each active tES condition against sham did not show differences in AM task performance either on recognition or cued-recall. However, data showed variability in performance depending on the task and the outcome measures. To explore the potential sources of variability in effect expression, analysis of the function-relevant neurophysiological markers is necessary. Therefore, behavioral results will be accompanied by features of underlying brain activity extracted from the EEG signals. Apart from introducing a novel approach to probing AM with personalized tES, this well-powered, multi-protocol, multi-task, and multi-measure study produced a comprehensive dataset that allows exploration of factors that could uncover different patterns in responsiveness to tES, as well as the insight into how neurophysiological changes reflected on the behavioral level.", publisher = "Elsevier", journal = "IBRO 11th World Congress of Neuroscience Supplement 1", title = "Towards understanding the neural underpinnings of associative memory: A tES-EEG study", pages = "879", url = "https://hdl.handle.net/21.15107/rcub_reff_4887" }
Paunović, D., Bjekić, J., Vulić, K., Živanović, M., Konstantinović, U., Stanković, M.,& Filipović, S. R.. (2023). Towards understanding the neural underpinnings of associative memory: A tES-EEG study. in IBRO 11th World Congress of Neuroscience Supplement 1 Elsevier., 879. https://hdl.handle.net/21.15107/rcub_reff_4887
Paunović D, Bjekić J, Vulić K, Živanović M, Konstantinović U, Stanković M, Filipović SR. Towards understanding the neural underpinnings of associative memory: A tES-EEG study. in IBRO 11th World Congress of Neuroscience Supplement 1. 2023;:879. https://hdl.handle.net/21.15107/rcub_reff_4887 .
Paunović, Dunja, Bjekić, Jovana, Vulić, Katarina, Živanović, Marko, Konstantinović, Uroš, Stanković, Marija, Filipović, Saša R., "Towards understanding the neural underpinnings of associative memory: A tES-EEG study" in IBRO 11th World Congress of Neuroscience Supplement 1 (2023):879, https://hdl.handle.net/21.15107/rcub_reff_4887 .