GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression
Апстракт
Background: The hypothalamo-pituitary-adrenocortical (HPA) axis self-regulation is achieved via cortisol binding to mineralocorticoid (MR) and glucocorticoid receptors (GR). It is often disturbed in mental disorders, particularly in those where traumatic stress has been implicated, such as posttraumatic stress disorder and depression. Although dexamethasone suppression test (DST) is often used as diagnostic aid, the findings still vary. In search of the factors influencing the DST outcome, we examined the glucocorticoicl receptor (GR) gene Bell polymorphism. Methods: A total of 229 male subjects were classified into three Bell groups: two groups with homozygous carriers (of the G allele, N=108, and of the C allele, N=26), and one with heterozygous carriers (N=95). Multiple hierarchical linear regression analysis was clone, where the dependent variable was the clexamethasone-inclucecl cortisol suppression, and predictors included receptor variables. The interactions of the count of 'G's... with the predictors were introduced to single out the effects of the G allele. Results: The means of all studied variables, including suppression, are statistically the same in the three groups. However, the mechanism of suppression involves MRs only in the G allele carriers. Limitations: The subjects were selected by criteria suited for the aim of the large project whose part is this study, hence the relatively small number of CC carriers. Also, we did not assess MR functional properties that would probably sharpen the results. Conclusion: Our finding that MRs participate in cortisol suppression in the G allele carriers suggests that research aimed at refining HPA axis-based therapy might require its adjustment for such patients.,
Кључне речи:
Mineralocorticoid receptor / GR gene snp BclI / Glucocorticoid receptor / Dexamethasone suppression testИзвор:
Journal of Affective Disorders, 2014, 168, 1-4Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
- European Commission Joint Research Centre [INCO-CT-2004-509213]
- Идентификација, мерење и развој когнитивних и емоционалних компетенција важних друштву оријентисаном на европске интеграције (RS-MESTD-Basic Research (BR or ON)-179018)
- Улога стероидних хормона у неуроендокриној адаптацији на стрес и патофизиологији метаболичког синдрома - молекуларни механизми и клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.1016/j.jad.2014.06.046
ISSN: 0165-0327
PubMed: 25033471
WoS: 000341483100001
Scopus: 2-s2.0-84904552030
Институција/група
Psihologija / PsychologyTY - JOUR AU - Savić, Danka AU - Knežević, Goran AU - Damjanović, Svetozar AU - Antić, Jadranka AU - Matić, Gordana PY - 2014 UR - http://reff.f.bg.ac.rs/handle/123456789/1812 AB - Background: The hypothalamo-pituitary-adrenocortical (HPA) axis self-regulation is achieved via cortisol binding to mineralocorticoid (MR) and glucocorticoid receptors (GR). It is often disturbed in mental disorders, particularly in those where traumatic stress has been implicated, such as posttraumatic stress disorder and depression. Although dexamethasone suppression test (DST) is often used as diagnostic aid, the findings still vary. In search of the factors influencing the DST outcome, we examined the glucocorticoicl receptor (GR) gene Bell polymorphism. Methods: A total of 229 male subjects were classified into three Bell groups: two groups with homozygous carriers (of the G allele, N=108, and of the C allele, N=26), and one with heterozygous carriers (N=95). Multiple hierarchical linear regression analysis was clone, where the dependent variable was the clexamethasone-inclucecl cortisol suppression, and predictors included receptor variables. The interactions of the count of 'G's with the predictors were introduced to single out the effects of the G allele. Results: The means of all studied variables, including suppression, are statistically the same in the three groups. However, the mechanism of suppression involves MRs only in the G allele carriers. Limitations: The subjects were selected by criteria suited for the aim of the large project whose part is this study, hence the relatively small number of CC carriers. Also, we did not assess MR functional properties that would probably sharpen the results. Conclusion: Our finding that MRs participate in cortisol suppression in the G allele carriers suggests that research aimed at refining HPA axis-based therapy might require its adjustment for such patients., PB - Elsevier Science BV, Amsterdam T2 - Journal of Affective Disorders T1 - GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression EP - 4 SP - 1 VL - 168 DO - 10.1016/j.jad.2014.06.046 ER -
@article{ author = "Savić, Danka and Knežević, Goran and Damjanović, Svetozar and Antić, Jadranka and Matić, Gordana", year = "2014", abstract = "Background: The hypothalamo-pituitary-adrenocortical (HPA) axis self-regulation is achieved via cortisol binding to mineralocorticoid (MR) and glucocorticoid receptors (GR). It is often disturbed in mental disorders, particularly in those where traumatic stress has been implicated, such as posttraumatic stress disorder and depression. Although dexamethasone suppression test (DST) is often used as diagnostic aid, the findings still vary. In search of the factors influencing the DST outcome, we examined the glucocorticoicl receptor (GR) gene Bell polymorphism. Methods: A total of 229 male subjects were classified into three Bell groups: two groups with homozygous carriers (of the G allele, N=108, and of the C allele, N=26), and one with heterozygous carriers (N=95). Multiple hierarchical linear regression analysis was clone, where the dependent variable was the clexamethasone-inclucecl cortisol suppression, and predictors included receptor variables. The interactions of the count of 'G's with the predictors were introduced to single out the effects of the G allele. Results: The means of all studied variables, including suppression, are statistically the same in the three groups. However, the mechanism of suppression involves MRs only in the G allele carriers. Limitations: The subjects were selected by criteria suited for the aim of the large project whose part is this study, hence the relatively small number of CC carriers. Also, we did not assess MR functional properties that would probably sharpen the results. Conclusion: Our finding that MRs participate in cortisol suppression in the G allele carriers suggests that research aimed at refining HPA axis-based therapy might require its adjustment for such patients.,", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Affective Disorders", title = "GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression", pages = "4-1", volume = "168", doi = "10.1016/j.jad.2014.06.046" }
Savić, D., Knežević, G., Damjanović, S., Antić, J.,& Matić, G.. (2014). GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression. in Journal of Affective Disorders Elsevier Science BV, Amsterdam., 168, 1-4. https://doi.org/10.1016/j.jad.2014.06.046
Savić D, Knežević G, Damjanović S, Antić J, Matić G. GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression. in Journal of Affective Disorders. 2014;168:1-4. doi:10.1016/j.jad.2014.06.046 .
Savić, Danka, Knežević, Goran, Damjanović, Svetozar, Antić, Jadranka, Matić, Gordana, "GR gene BclI polymorphysm changes the path, but not the level, of dexamethasone-induced cortisol suppression" in Journal of Affective Disorders, 168 (2014):1-4, https://doi.org/10.1016/j.jad.2014.06.046 . .