PTSD and depressive symptoms are linked to DHEAS via personality
Apstrakt
Background Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are i...ndirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.
Ključne reči:
Structure equation model / Post-traumatic stress disorder / Personality traits / DHEAS / DepressionIzvor:
Psychoneuroendocrinology, 2018, 92, 29-33Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- European Commission Joint Research Centre [INCO-CT-2004-509213]
- Identifikacija, merenje i razvoj kognitivnih i emocionalnih kompetencija važnih društvu orijentisanom na evropske integracije (RS-MESTD-Basic Research (BR or ON)-179018)
DOI: 10.1016/j.psyneuen.2018.03.017
ISSN: 0306-4530
PubMed: 29621722
WoS: 000433266200004
Scopus: 2-s2.0-85044739815
Institucija/grupa
Psihologija / PsychologyTY - JOUR AU - Savić, Danka AU - Knežević, Goran AU - Matić, Gordana AU - Damjanović, Svetozar PY - 2018 UR - http://reff.f.bg.ac.rs/handle/123456789/2691 AB - Background Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Psychoneuroendocrinology T1 - PTSD and depressive symptoms are linked to DHEAS via personality EP - 33 SP - 29 VL - 92 DO - 10.1016/j.psyneuen.2018.03.017 ER -
@article{ author = "Savić, Danka and Knežević, Goran and Matić, Gordana and Damjanović, Svetozar", year = "2018", abstract = "Background Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Psychoneuroendocrinology", title = "PTSD and depressive symptoms are linked to DHEAS via personality", pages = "33-29", volume = "92", doi = "10.1016/j.psyneuen.2018.03.017" }
Savić, D., Knežević, G., Matić, G.,& Damjanović, S.. (2018). PTSD and depressive symptoms are linked to DHEAS via personality. in Psychoneuroendocrinology Pergamon-Elsevier Science Ltd, Oxford., 92, 29-33. https://doi.org/10.1016/j.psyneuen.2018.03.017
Savić D, Knežević G, Matić G, Damjanović S. PTSD and depressive symptoms are linked to DHEAS via personality. in Psychoneuroendocrinology. 2018;92:29-33. doi:10.1016/j.psyneuen.2018.03.017 .
Savić, Danka, Knežević, Goran, Matić, Gordana, Damjanović, Svetozar, "PTSD and depressive symptoms are linked to DHEAS via personality" in Psychoneuroendocrinology, 92 (2018):29-33, https://doi.org/10.1016/j.psyneuen.2018.03.017 . .