Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement
2022
Autori
Bjekić, JovanaŽivanović, Marko
Paunović, Dunja
Vulić, Katarina
Konstantinović, Uroš
Stanković, Marija
Filipović, Saša R.
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Noninvasive brain stimulation (NIBS) has gained increased interest in research of associative memory (AM) and its impairments. However, the one-size-fits-all approach yields inconsistent findings, thus putting forward the need for the development of personalized frequency-modulated NIBS protocols to increase the focality and the effectiveness of the interventions. Specifically, transcranial altering current stimulation (tACS) and transcranial oscillatory current stimulation (otDCS) with theta-band frequencies (4-8Hz) are promising path for further AM-directed neuromodulation. The aim of the current study was (1) to develop a method for extracting the individual theta-band frequency (ITF) to be used as an input parameter for personalized theta-modulated tACS and otDCS; (2) to assess the effects of tACS and otDCS in comparison to constant anodal tDCS and sham on different AM measures including short-term AM, delayed recognition, and cued recall. In a sample of 42 healthy volunteers, we e...xtracted the frequencies with the highest event-related spectral perturbation from 19 overlapping time windows and six centroparietal electrodes from the EEG signal recorded during successful encoding in an AM task. The ITF was defined as modal frequency (4-8 Hz in 0.5 Hz steps) in the time x electrode matrix. The method showed a 93% success rate, good reliability, and a full range of variability of the extracted ITFs. In a cross-over counterbalanced design, different stimulation protocols (tACS/otDCS/tDCS/sham) were delivered in separate sessions (7 days apart) for 20 minutes over the posterior parietal cortex. Results showed either AM enhancement or no effects of tACS/otDCS/tDCS, depending on the outcome measure that was used. We will discuss individual differences in theta-band activity during AM encoding, together with ITF-extraction challenges and possible methodological and conceptual explanations for the inconsistent effects.
Ključne reči:
noninvasive brain stimulation (nibs) / transcranial alternating current stimulation (tacs) / transcranial oscillatory current stimulation (otdcs) / theta-band / eeg / individual theta-band frequency (itf)Izvor:
Clinical Neurophysiology, 2022, 141, S2-Finansiranje / projekti:
- Horizon Europe - project “Twinning for excellence in non-invasive brain stimulation in Western Balkans” (project no 101059369)
- Ministry of Education, Science, and Technological development of the Republic of Serbia (University of Belgrade, Institute for Medical Research - grant no. 451-03- 68/2022-14/200015)
- Ministry of Education, Science, and Technological development of the Republic of Serbia (University of Belgrade, Faculty of Philosophy - grant no. 451-03-68/2022-14/200163)
Institucija/grupa
Psihologija / PsychologyTY - CONF AU - Bjekić, Jovana AU - Živanović, Marko AU - Paunović, Dunja AU - Vulić, Katarina AU - Konstantinović, Uroš AU - Stanković, Marija AU - Filipović, Saša R. PY - 2022 UR - http://reff.f.bg.ac.rs/handle/123456789/4859 AB - Noninvasive brain stimulation (NIBS) has gained increased interest in research of associative memory (AM) and its impairments. However, the one-size-fits-all approach yields inconsistent findings, thus putting forward the need for the development of personalized frequency-modulated NIBS protocols to increase the focality and the effectiveness of the interventions. Specifically, transcranial altering current stimulation (tACS) and transcranial oscillatory current stimulation (otDCS) with theta-band frequencies (4-8Hz) are promising path for further AM-directed neuromodulation. The aim of the current study was (1) to develop a method for extracting the individual theta-band frequency (ITF) to be used as an input parameter for personalized theta-modulated tACS and otDCS; (2) to assess the effects of tACS and otDCS in comparison to constant anodal tDCS and sham on different AM measures including short-term AM, delayed recognition, and cued recall. In a sample of 42 healthy volunteers, we extracted the frequencies with the highest event-related spectral perturbation from 19 overlapping time windows and six centroparietal electrodes from the EEG signal recorded during successful encoding in an AM task. The ITF was defined as modal frequency (4-8 Hz in 0.5 Hz steps) in the time x electrode matrix. The method showed a 93% success rate, good reliability, and a full range of variability of the extracted ITFs. In a cross-over counterbalanced design, different stimulation protocols (tACS/otDCS/tDCS/sham) were delivered in separate sessions (7 days apart) for 20 minutes over the posterior parietal cortex. Results showed either AM enhancement or no effects of tACS/otDCS/tDCS, depending on the outcome measure that was used. We will discuss individual differences in theta-band activity during AM encoding, together with ITF-extraction challenges and possible methodological and conceptual explanations for the inconsistent effects. C3 - Clinical Neurophysiology T1 - Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement SP - S2 VL - 141 DO - 10.1016/j.clinph.2022.07.008 ER -
@conference{ author = "Bjekić, Jovana and Živanović, Marko and Paunović, Dunja and Vulić, Katarina and Konstantinović, Uroš and Stanković, Marija and Filipović, Saša R.", year = "2022", abstract = "Noninvasive brain stimulation (NIBS) has gained increased interest in research of associative memory (AM) and its impairments. However, the one-size-fits-all approach yields inconsistent findings, thus putting forward the need for the development of personalized frequency-modulated NIBS protocols to increase the focality and the effectiveness of the interventions. Specifically, transcranial altering current stimulation (tACS) and transcranial oscillatory current stimulation (otDCS) with theta-band frequencies (4-8Hz) are promising path for further AM-directed neuromodulation. The aim of the current study was (1) to develop a method for extracting the individual theta-band frequency (ITF) to be used as an input parameter for personalized theta-modulated tACS and otDCS; (2) to assess the effects of tACS and otDCS in comparison to constant anodal tDCS and sham on different AM measures including short-term AM, delayed recognition, and cued recall. In a sample of 42 healthy volunteers, we extracted the frequencies with the highest event-related spectral perturbation from 19 overlapping time windows and six centroparietal electrodes from the EEG signal recorded during successful encoding in an AM task. The ITF was defined as modal frequency (4-8 Hz in 0.5 Hz steps) in the time x electrode matrix. The method showed a 93% success rate, good reliability, and a full range of variability of the extracted ITFs. In a cross-over counterbalanced design, different stimulation protocols (tACS/otDCS/tDCS/sham) were delivered in separate sessions (7 days apart) for 20 minutes over the posterior parietal cortex. Results showed either AM enhancement or no effects of tACS/otDCS/tDCS, depending on the outcome measure that was used. We will discuss individual differences in theta-band activity during AM encoding, together with ITF-extraction challenges and possible methodological and conceptual explanations for the inconsistent effects.", journal = "Clinical Neurophysiology", title = "Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement", pages = "S2", volume = "141", doi = "10.1016/j.clinph.2022.07.008" }
Bjekić, J., Živanović, M., Paunović, D., Vulić, K., Konstantinović, U., Stanković, M.,& Filipović, S. R.. (2022). Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement. in Clinical Neurophysiology, 141, S2. https://doi.org/10.1016/j.clinph.2022.07.008
Bjekić J, Živanović M, Paunović D, Vulić K, Konstantinović U, Stanković M, Filipović SR. Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement. in Clinical Neurophysiology. 2022;141:S2. doi:10.1016/j.clinph.2022.07.008 .
Bjekić, Jovana, Živanović, Marko, Paunović, Dunja, Vulić, Katarina, Konstantinović, Uroš, Stanković, Marija, Filipović, Saša R., "Personalized theta frequency-modulated transcranial electric stimulation for associative memory improvement" in Clinical Neurophysiology, 141 (2022):S2, https://doi.org/10.1016/j.clinph.2022.07.008 . .