TY  - JOUR
AU  - Preković, Stefan
AU  - Filipović Đurđević, Dušica
AU  - Csifcsak, Gabor
AU  - Sveljo, Olivera
AU  - Stojković, Oliver
AU  - Janković, Milica M.
AU  - Koprivsek, Katarina
AU  - Covill, Laura E.
AU  - Lucić, Miloš
AU  - Van den Broeck, Thomas
AU  - Helsen, Christine
AU  - Ceroni, Fabiola
AU  - Claessens, Frank
AU  - Newbury, Dianne F.
PY  - 2016
UR  - http://reff.f.bg.ac.rs/handle/123456789/2114
AB  - Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation
VL  - 6
DO  - 10.1038/srep20369
ER  - 

@article{
author = "Preković, Stefan and Filipović Đurđević, Dušica and Csifcsak, Gabor and Sveljo, Olivera and Stojković, Oliver and Janković, Milica M. and Koprivsek, Katarina and Covill, Laura E. and Lucić, Miloš and Van den Broeck, Thomas and Helsen, Christine and Ceroni, Fabiola and Claessens, Frank and Newbury, Dianne F.",
year = "2016",
abstract = "Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation",
volume = "6",
doi = "10.1038/srep20369"
}

Preković, S., Filipović Đurđević, D., Csifcsak, G., Sveljo, O., Stojković, O., Janković, M. M., Koprivsek, K., Covill, L. E., Lucić, M., Van den Broeck, T., Helsen, C., Ceroni, F., Claessens, F.,& Newbury, D. F.. (2016). Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation. in Scientific Reports
Nature Publishing Group, London., 6.
https://doi.org/10.1038/srep20369

Preković S, Filipović Đurđević D, Csifcsak G, Sveljo O, Stojković O, Janković MM, Koprivsek K, Covill LE, Lucić M, Van den Broeck T, Helsen C, Ceroni F, Claessens F, Newbury DF. Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation. in Scientific Reports. 2016;6.
doi:10.1038/srep20369 .

Preković, Stefan, Filipović Đurđević, Dušica, Csifcsak, Gabor, Sveljo, Olivera, Stojković, Oliver, Janković, Milica M., Koprivsek, Katarina, Covill, Laura E., Lucić, Miloš, Van den Broeck, Thomas, Helsen, Christine, Ceroni, Fabiola, Claessens, Frank, Newbury, Dianne F., "Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation" in Scientific Reports, 6 (2016),
https://doi.org/10.1038/srep20369 . .