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Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'

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2012
Authors
Savić, Danka
Knežević, Goran
Damjanović, Svetozar
Spirić, Željko
Matić, Gordana
Article (Published version)
Metadata
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Abstract
The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol sup...pression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.

Keywords:
Traumatic experiences / Post-traumatic stress disorder / Low dose dexamethasone suppression test / Depression
Source:
Psychoneuroendocrinology, 2012, 37, 9, 1516-1520
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
  • European Commission Joint Research Centre [INCO-CT-2004-509213]
  • Identification, measurement and development of the cognitive and emotional competences important for a Europe-oriented society (RS-179018)
  • Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-41009)

DOI: 10.1016/j.psyneuen.2012.02.005

ISSN: 0306-4530

PubMed: 22398269

WoS: 000307678800015

Scopus: 2-s2.0-84864739352
[ Google Scholar ]
16
14
URI
http://reff.f.bg.ac.rs/handle/123456789/1338
Collections
  • Radovi istraživača / Researcher's publications - Odeljenje za psihologiju
Institution/Community
Psihologija / Psychology
TY  - JOUR
AU  - Savić, Danka
AU  - Knežević, Goran
AU  - Damjanović, Svetozar
AU  - Spirić, Željko
AU  - Matić, Gordana
PY  - 2012
UR  - http://reff.f.bg.ac.rs/handle/123456789/1338
AB  - The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Psychoneuroendocrinology
T1  - Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'
EP  - 1520
IS  - 9
SP  - 1516
VL  - 37
DO  - 10.1016/j.psyneuen.2012.02.005
ER  - 
@article{
author = "Savić, Danka and Knežević, Goran and Damjanović, Svetozar and Spirić, Željko and Matić, Gordana",
year = "2012",
abstract = "The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Psychoneuroendocrinology",
title = "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'",
pages = "1520-1516",
number = "9",
volume = "37",
doi = "10.1016/j.psyneuen.2012.02.005"
}
Savić, D., Knežević, G., Damjanović, S., Spirić, Ž.,& Matić, G.. (2012). Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology
Pergamon-Elsevier Science Ltd, Oxford., 37(9), 1516-1520.
https://doi.org/10.1016/j.psyneuen.2012.02.005
Savić D, Knežević G, Damjanović S, Spirić Ž, Matić G. Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology. 2012;37(9):1516-1520.
doi:10.1016/j.psyneuen.2012.02.005 .
Savić, Danka, Knežević, Goran, Damjanović, Svetozar, Spirić, Željko, Matić, Gordana, "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'" in Psychoneuroendocrinology, 37, no. 9 (2012):1516-1520,
https://doi.org/10.1016/j.psyneuen.2012.02.005 . .

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