Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'
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2012
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The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol sup...pression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.
Ključne reči:
Traumatic experiences / Post-traumatic stress disorder / Low dose dexamethasone suppression test / DepressionIzvor:
Psychoneuroendocrinology, 2012, 37, 9, 1516-1520Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- European Commission Joint Research Centre [INCO-CT-2004-509213]
- Identifikacija, merenje i razvoj kognitivnih i emocionalnih kompetencija važnih društvu orijentisanom na evropske integracije (RS-MESTD-Basic Research (BR or ON)-179018)
- Uloga steroidnih hormona u neuroendokrinoj adaptaciji na stres i patofiziologiji metaboličkog sindroma - molekularni mehanizmi i kliničke implikacije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
DOI: 10.1016/j.psyneuen.2012.02.005
ISSN: 0306-4530
PubMed: 22398269
WoS: 000307678800015
Scopus: 2-s2.0-84864739352
Institucija/grupa
Psihologija / PsychologyTY - JOUR AU - Savić, Danka AU - Knežević, Goran AU - Damjanović, Svetozar AU - Spirić, Željko AU - Matić, Gordana PY - 2012 UR - http://reff.f.bg.ac.rs/handle/123456789/1338 AB - The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Psychoneuroendocrinology T1 - Is there a biological difference between trauma-related depression and PTSD? DST says 'NO' EP - 1520 IS - 9 SP - 1516 VL - 37 DO - 10.1016/j.psyneuen.2012.02.005 ER -
@article{ author = "Savić, Danka and Knežević, Goran and Damjanović, Svetozar and Spirić, Željko and Matić, Gordana", year = "2012", abstract = "The use of the low-dose dexamethasone suppression test (DST) as a potentially discriminative marker between post-traumatic stress disorder (PTSD) and depression is still under discussion. In order to compare the influence of these psychopathologies on the DST results, we examined suppression in war-traumatized subjects with one or both of these disorders, as well as in healthy controls. Based on our previous findings, we hypothesized that subjects with any disorder would exhibit higher dexamethasone suppression than healthy controls due to traumatic experiences. This study was a part of a broader project in which simultaneous psychological and biological investigations were carried out in hospital conditions on 399 mate participants: 57 with PTSD, 28 with depression, 76 with PTSD + depression, and 238 healthy controls. Cortisol was measured in blood samples taken at 0900 h before and after administering 0.5 mg of dexamethasone (at 2300 h). Group means standard deviation of cortisol suppression were: 79.4 +/- 18.5 in the PTSD group, 80.8 +/- 11.6 in the depression group, 77.5 +/- 24.6 in the group with PTSD+depression, and 66.8 +/- 34.6 in healthy controls. The first three groups suppressed significantly more than the fourth. When the number of traumas was introduced as a covariate, the differences disappeared. The hypothesis was confirmed: in respect to DST, the examined trauma-related psychopathologies showed the same pattern: hypersuppression, due to multiple traumatic experiences.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Psychoneuroendocrinology", title = "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'", pages = "1520-1516", number = "9", volume = "37", doi = "10.1016/j.psyneuen.2012.02.005" }
Savić, D., Knežević, G., Damjanović, S., Spirić, Ž.,& Matić, G.. (2012). Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology Pergamon-Elsevier Science Ltd, Oxford., 37(9), 1516-1520. https://doi.org/10.1016/j.psyneuen.2012.02.005
Savić D, Knežević G, Damjanović S, Spirić Ž, Matić G. Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'. in Psychoneuroendocrinology. 2012;37(9):1516-1520. doi:10.1016/j.psyneuen.2012.02.005 .
Savić, Danka, Knežević, Goran, Damjanović, Svetozar, Spirić, Željko, Matić, Gordana, "Is there a biological difference between trauma-related depression and PTSD? DST says 'NO'" in Psychoneuroendocrinology, 37, no. 9 (2012):1516-1520, https://doi.org/10.1016/j.psyneuen.2012.02.005 . .