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dc.creatorMatić, Gordana
dc.creatorVojnović-Milutinović, Danijela
dc.creatorNestorov, Jelena
dc.creatorElaković, Ivana
dc.creatorManitašević-Jovanović, Sanja
dc.creatorPerišić, Tatjana
dc.creatorDunderski, Jadranka
dc.creatorDamjanović, Svetozar
dc.creatorKnežević, Goran
dc.creatorSpirić, Željko
dc.creatorVermetten, Eric
dc.creatorSavić, Danka
dc.date.accessioned2021-10-12T11:45:07Z
dc.date.available2021-10-12T11:45:07Z
dc.date.issued2013
dc.identifier.issn0278-5846
dc.identifier.urihttp://reff.f.bg.ac.rs/handle/123456789/1626
dc.description.abstractObjective: Posttraumatic stress disorder (PTSD) has been shown to be associated with altered glucocorticoid receptor (GR) activity. We studied the expression and functional properties of the receptor in peripheral blood mononuclear cells (PBMCs) from non-traumatized healthy individuals (healthy controls; n = 85), and war trauma-exposed individuals with current PTSD (n = 113), with life-time PTSD (n = 61) and without PTSD (trauma controls; n = 88). The aim of the study was to distinguish the receptor alterations related to PTSD from those related to trauma itself or to resilience to PTSD. Methods: Functional status of the receptor was assessed by radioligand binding and lysozyme synthesis inhibition assays. The level of GR gene expression was measured by quantitative PCR and immunoblotting. Results: Current PTSD patients had the lowest, while trauma controls had the highest number of glucocorticoid binding sites (B-max) in PBMCs. Hormone-binding potential (B-max/K-D ratio) of the receptor was diminished in the current PTSD group in comparison to all other study groups. Correlation between B-max and K-D that normally exists in healthy individuals was decreased in the current PTSD group. Contrasting B-max data, GR protein level was lower in trauma controls than in participants with current or life-time PTSD. Conclusions: Current PTSD is characterized by reduced lymphocyte GR hormone-binding potential and by disturbed compensation between B-max and hormone-binding affinity. Resilience to PTSD is associated with enlarged fraction of the receptor molecules capable of hormone binding, within the total receptor molecule population in PBMCs.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationEuropean Commission Joint Research Centre [INCO-CT-2004-509213]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/179018/RS//
dc.rightsrestrictedAccess
dc.sourceProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.subjectWar traumaen
dc.subjectResilience to PTSDen
dc.subjectPTSDen
dc.subjectPeripheral blood mononuclear cellsen
dc.subjectGlucocorticoid receptoren
dc.titleLymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSDen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage245
dc.citation.other43: 238-245
dc.citation.rankM21
dc.citation.spage238
dc.citation.volume43
dc.identifier.doi10.1016/j.pnpbp.2013.01.005
dc.identifier.pmid23333536
dc.identifier.scopus2-s2.0-84873550690
dc.identifier.wos000317878700031
dc.type.versionpublishedVersion


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