Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
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Matić, Gordana
Vojnović-Milutinović, Danijela

Nestorov, Jelena

Elaković, Ivana
Manitašević-Jovanović, Sanja

Elzaedi, Younis Mouftah
Perišić, Tatjana
Dunderski, Jadranka
Damjanović, Svetozar
Knežević, Goran

Spirić, Željko
Vermetten, Eric

Savić, Danka

Article (Published version)

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Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was corr...elated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins.
Keywords:
War trauma / PTSD / Mineralocorticoid receptor / Hsp90 / Hsp70 / Glucocorticoid receptorSource:
Psychiatry Research, 2014, 215, 2, 379-385Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
- European Commision [INCO-CT-2004-509213]
- Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-41009)
- Identification, measurement and development of the cognitive and emotional competences important for a Europe-oriented society (RS-179018)
DOI: 10.1016/j.psychres.2013.11.022
ISSN: 0165-1781
PubMed: 24355684
WoS: 000332355800019
Scopus: 2-s2.0-84893756193
Institution/Community
Psihologija / PsychologyTY - JOUR AU - Matić, Gordana AU - Vojnović-Milutinović, Danijela AU - Nestorov, Jelena AU - Elaković, Ivana AU - Manitašević-Jovanović, Sanja AU - Elzaedi, Younis Mouftah AU - Perišić, Tatjana AU - Dunderski, Jadranka AU - Damjanović, Svetozar AU - Knežević, Goran AU - Spirić, Željko AU - Vermetten, Eric AU - Savić, Danka PY - 2014 UR - http://reff.f.bg.ac.rs/handle/123456789/1796 AB - Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. PB - Elsevier Ireland Ltd, Clare T2 - Psychiatry Research T1 - Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD EP - 385 IS - 2 SP - 379 VL - 215 DO - 10.1016/j.psychres.2013.11.022 ER -
@article{ author = "Matić, Gordana and Vojnović-Milutinović, Danijela and Nestorov, Jelena and Elaković, Ivana and Manitašević-Jovanović, Sanja and Elzaedi, Younis Mouftah and Perišić, Tatjana and Dunderski, Jadranka and Damjanović, Svetozar and Knežević, Goran and Spirić, Željko and Vermetten, Eric and Savić, Danka", year = "2014", abstract = "Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Psychiatry Research", title = "Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD", pages = "385-379", number = "2", volume = "215", doi = "10.1016/j.psychres.2013.11.022" }
Matić, G., Vojnović-Milutinović, D., Nestorov, J., Elaković, I., Manitašević-Jovanović, S., Elzaedi, Y. M., Perišić, T., Dunderski, J., Damjanović, S., Knežević, G., Spirić, Ž., Vermetten, E.,& Savić, D.. (2014). Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research Elsevier Ireland Ltd, Clare., 215(2), 379-385. https://doi.org/10.1016/j.psychres.2013.11.022
Matić G, Vojnović-Milutinović D, Nestorov J, Elaković I, Manitašević-Jovanović S, Elzaedi YM, Perišić T, Dunderski J, Damjanović S, Knežević G, Spirić Ž, Vermetten E, Savić D. Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. in Psychiatry Research. 2014;215(2):379-385. doi:10.1016/j.psychres.2013.11.022 .
Matić, Gordana, Vojnović-Milutinović, Danijela, Nestorov, Jelena, Elaković, Ivana, Manitašević-Jovanović, Sanja, Elzaedi, Younis Mouftah, Perišić, Tatjana, Dunderski, Jadranka, Damjanović, Svetozar, Knežević, Goran, Spirić, Željko, Vermetten, Eric, Savić, Danka, "Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD" in Psychiatry Research, 215, no. 2 (2014):379-385, https://doi.org/10.1016/j.psychres.2013.11.022 . .