Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation

2016
Authors
Preković, Stefan
Filipović Đurđević, Dušica

Csifcsak, Gabor

Sveljo, Olivera

Stojković, Oliver

Janković, Milica M.

Koprivsek, Katarina
Covill, Laura E.

Lucić, Miloš
Van den Broeck, Thomas

Helsen, Christine

Ceroni, Fabiola
Claessens, Frank

Newbury, Dianne F.
Article (Published version)
Metadata
Show full item recordAbstract
Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is affor...ded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.
Source:
Scientific Reports, 2016, 6Publisher:
- Nature Publishing Group, London
Funding / projects:
- Psychological foundations of mental health: hereditary and environmental factors (RS-179006)
- National Brain Research Program [KTIA_13_NAP-A-II/20]
- Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences
- Medical Research Council and UK Research & Innovation [G1000569/1, MR/J003719/1]
- Wellcome Trust European Commission [090532/Z/09/Z]
- UK Research & Innovation (UKRI) and Medical Research Council UK (MRC) [G0900747 91070]
- Medical Research Council and UK Research & Innovation [G1000569]
DOI: 10.1038/srep20369
ISSN: 2045-2322
PubMed: 26838027
WoS: 000369785800001
Scopus: 2-s2.0-84957607385
Institution/Community
Psihologija / PsychologyTY - JOUR AU - Preković, Stefan AU - Filipović Đurđević, Dušica AU - Csifcsak, Gabor AU - Sveljo, Olivera AU - Stojković, Oliver AU - Janković, Milica M. AU - Koprivsek, Katarina AU - Covill, Laura E. AU - Lucić, Miloš AU - Van den Broeck, Thomas AU - Helsen, Christine AU - Ceroni, Fabiola AU - Claessens, Frank AU - Newbury, Dianne F. PY - 2016 UR - http://reff.f.bg.ac.rs/handle/123456789/2114 AB - Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors. PB - Nature Publishing Group, London T2 - Scientific Reports T1 - Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation VL - 6 DO - 10.1038/srep20369 ER -
@article{ author = "Preković, Stefan and Filipović Đurđević, Dušica and Csifcsak, Gabor and Sveljo, Olivera and Stojković, Oliver and Janković, Milica M. and Koprivsek, Katarina and Covill, Laura E. and Lucić, Miloš and Van den Broeck, Thomas and Helsen, Christine and Ceroni, Fabiola and Claessens, Frank and Newbury, Dianne F.", year = "2016", abstract = "Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.", publisher = "Nature Publishing Group, London", journal = "Scientific Reports", title = "Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation", volume = "6", doi = "10.1038/srep20369" }
Preković, S., Filipović Đurđević, D., Csifcsak, G., Sveljo, O., Stojković, O., Janković, M. M., Koprivsek, K., Covill, L. E., Lucić, M., Van den Broeck, T., Helsen, C., Ceroni, F., Claessens, F.,& Newbury, D. F.. (2016). Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation. in Scientific Reports Nature Publishing Group, London., 6. https://doi.org/10.1038/srep20369
Preković S, Filipović Đurđević D, Csifcsak G, Sveljo O, Stojković O, Janković MM, Koprivsek K, Covill LE, Lucić M, Van den Broeck T, Helsen C, Ceroni F, Claessens F, Newbury DF. Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation. in Scientific Reports. 2016;6. doi:10.1038/srep20369 .
Preković, Stefan, Filipović Đurđević, Dušica, Csifcsak, Gabor, Sveljo, Olivera, Stojković, Oliver, Janković, Milica M., Koprivsek, Katarina, Covill, Laura E., Lucić, Miloš, Van den Broeck, Thomas, Helsen, Christine, Ceroni, Fabiola, Claessens, Frank, Newbury, Dianne F., "Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation" in Scientific Reports, 6 (2016), https://doi.org/10.1038/srep20369 . .