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Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders

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Authors
Milovanović, Maja
Radivojević, Vlada
Radosavljev-Kircanski, Jelena
Grujičić, Roberto
Tošković, Oliver
Aleksic-Hil, Olivera
Pejović-Milovančević, Milica
Article (Published version)
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Abstract
Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Clinical assessment for epilepsy and video electroencephalography (EEG) (v-EEG) examinations during wakefulness and/or sleep were prospectively performed in all patients. Results: A total of 112 patients with diagnosis of ASD of mean age 6.58 +/- 3.72 were included in the study. Based on clinical and v-EEG assessments, three groups of patients were defined: 1) patients with epilepsy (n = 17; 15.2%); 2) patients with epileptiform discharges in absence of clinical seizures (n = 14; 12.5%); 3) patients without epi...lepsy and without epileptiform discharges ( n = 81; 72.3%). There were no significant differences between three groups of patients on ADI-R subscores. Speech development was also not significantly related to epilepsy. There was a slight tendency of the VABS-II motor skills score to be higher in the group of patients with autism without clinical diagnosis of epilepsy and without subclinical epileptiform discharges (p lt 0.05) in comparison with the two other groups. According to this tendency, we might claim that patients with higher scores on motor skills could have 0.88 times lower odds for having epileptiform EEG activity. Conclusions: According to our results, we were not able to detect differences in the ADI-R between the three populations with ASD, all with unknown etiology. Epilepsy, as well as subdinical epileptic discharges, showed small effects on Motor Skills in patients with autism, and had no effect on adaptive behavior Communication/Socialization/Daily Living Skills.

Keywords:
Epileptic discharges / Epilepsy / EEG / Autism spectrum disorders / Adaptive behavior
Source:
Epilepsy & Behavior, 2019, 92, 45-52
Publisher:
  • Academic Press Inc Elsevier Science, San Diego

DOI: 10.1016/j.yebeh.2018.12.011

ISSN: 1525-5050

PubMed: 30611007

WoS: 000461905800008

Scopus: 2-s2.0-85059348800
[ Google Scholar ]
11
9
URI
http://reff.f.bg.ac.rs/handle/123456789/2821
Collections
  • Radovi istraživača / Researcher's publications - Odeljenje za psihologiju
Institution/Community
Psihologija / Psychology
TY  - JOUR
AU  - Milovanović, Maja
AU  - Radivojević, Vlada
AU  - Radosavljev-Kircanski, Jelena
AU  - Grujičić, Roberto
AU  - Tošković, Oliver
AU  - Aleksic-Hil, Olivera
AU  - Pejović-Milovančević, Milica
PY  - 2019
UR  - http://reff.f.bg.ac.rs/handle/123456789/2821
AB  - Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Clinical assessment for epilepsy and video electroencephalography (EEG) (v-EEG) examinations during wakefulness and/or sleep were prospectively performed in all patients. Results: A total of 112 patients with diagnosis of ASD of mean age 6.58 +/- 3.72 were included in the study. Based on clinical and v-EEG assessments, three groups of patients were defined: 1) patients with epilepsy (n = 17; 15.2%); 2) patients with epileptiform discharges in absence of clinical seizures (n = 14; 12.5%); 3) patients without epilepsy and without epileptiform discharges ( n = 81; 72.3%). There were no significant differences between three groups of patients on ADI-R subscores. Speech development was also not significantly related to epilepsy. There was a slight tendency of the VABS-II motor skills score to be higher in the group of patients with autism without clinical diagnosis of epilepsy and without subclinical epileptiform discharges (p  lt  0.05) in comparison with the two other groups. According to this tendency, we might claim that patients with higher scores on motor skills could have 0.88 times lower odds for having epileptiform EEG activity. Conclusions: According to our results, we were not able to detect differences in the ADI-R between the three populations with ASD, all with unknown etiology. Epilepsy, as well as subdinical epileptic discharges, showed small effects on Motor Skills in patients with autism, and had no effect on adaptive behavior Communication/Socialization/Daily Living Skills.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Epilepsy & Behavior
T1  - Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders
EP  - 52
SP  - 45
VL  - 92
DO  - 10.1016/j.yebeh.2018.12.011
ER  - 
@article{
author = "Milovanović, Maja and Radivojević, Vlada and Radosavljev-Kircanski, Jelena and Grujičić, Roberto and Tošković, Oliver and Aleksic-Hil, Olivera and Pejović-Milovančević, Milica",
year = "2019",
abstract = "Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Clinical assessment for epilepsy and video electroencephalography (EEG) (v-EEG) examinations during wakefulness and/or sleep were prospectively performed in all patients. Results: A total of 112 patients with diagnosis of ASD of mean age 6.58 +/- 3.72 were included in the study. Based on clinical and v-EEG assessments, three groups of patients were defined: 1) patients with epilepsy (n = 17; 15.2%); 2) patients with epileptiform discharges in absence of clinical seizures (n = 14; 12.5%); 3) patients without epilepsy and without epileptiform discharges ( n = 81; 72.3%). There were no significant differences between three groups of patients on ADI-R subscores. Speech development was also not significantly related to epilepsy. There was a slight tendency of the VABS-II motor skills score to be higher in the group of patients with autism without clinical diagnosis of epilepsy and without subclinical epileptiform discharges (p  lt  0.05) in comparison with the two other groups. According to this tendency, we might claim that patients with higher scores on motor skills could have 0.88 times lower odds for having epileptiform EEG activity. Conclusions: According to our results, we were not able to detect differences in the ADI-R between the three populations with ASD, all with unknown etiology. Epilepsy, as well as subdinical epileptic discharges, showed small effects on Motor Skills in patients with autism, and had no effect on adaptive behavior Communication/Socialization/Daily Living Skills.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Epilepsy & Behavior",
title = "Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders",
pages = "52-45",
volume = "92",
doi = "10.1016/j.yebeh.2018.12.011"
}
Milovanović, M., Radivojević, V., Radosavljev-Kircanski, J., Grujičić, R., Tošković, O., Aleksic-Hil, O.,& Pejović-Milovančević, M.. (2019). Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders. in Epilepsy & Behavior
Academic Press Inc Elsevier Science, San Diego., 92, 45-52.
https://doi.org/10.1016/j.yebeh.2018.12.011
Milovanović M, Radivojević V, Radosavljev-Kircanski J, Grujičić R, Tošković O, Aleksic-Hil O, Pejović-Milovančević M. Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders. in Epilepsy & Behavior. 2019;92:45-52.
doi:10.1016/j.yebeh.2018.12.011 .
Milovanović, Maja, Radivojević, Vlada, Radosavljev-Kircanski, Jelena, Grujičić, Roberto, Tošković, Oliver, Aleksic-Hil, Olivera, Pejović-Milovančević, Milica, "Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders" in Epilepsy & Behavior, 92 (2019):45-52,
https://doi.org/10.1016/j.yebeh.2018.12.011 . .

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