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Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory

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Authors
Bjekić, Jovana
Colić, Marija V.
Živanović, Marko
Milanović, Slađan D.
Filipović, Saša R.
Article (Published version)
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Abstract
Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Forty-two healthy adults participated in two sham-controlled cross-over experiments. Anodal electrode (20 min, 1.5 mA) was placed over P3 in Experiment 1 and over P4 in Experiment 2. During tDCS participants played a simple computer game. After each stimulation session, participants completed parallel forms of an associative memory task (Experiment 1: face-word memory; Experiment 2: object-location memory) and a c...ontrol task (verbal fluency). In both experiments, associative memory was improved after anodal stimulation compared to sham stimulation, while no differences were observed in the control task. Additionally, memory performance was higher in the second than in the first trial, but the increase in performance between the two trials did not differ between stimulation conditions. It can be concluded that a single-session anodal tDCS over posterior parietal cortex can improve associative memory performance. The specificity, robustness, and reproducibility of the effect suggest that PPC is a promising target for brain stimulation aiming to enhance memory functions.

Keywords:
Transcranial direct-current stimulation (tDCS) / Posterior parietal cortex (PPC) / Object-location memory / Face-word memory / Cognitive enhancement / Associative memory
Source:
Neurobiology of Learning and Memory, 2019, 157, 114-120
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Funding / projects:
  • Noninvasive modulation of cortical excitability and plasticity - Noninvasive neuromodulation of the CNS in the study of physiological mechanisms, diagnosis and treatment (RS-175012)

DOI: 10.1016/j.nlm.2018.12.007

ISSN: 1074-7427

PubMed: 30553021

WoS: 000460849900012

Scopus: 2-s2.0-85058468366
[ Google Scholar ]
22
13
URI
http://reff.f.bg.ac.rs/handle/123456789/2852
Collections
  • Radovi istraživača / Researcher's publications - Odeljenje za psihologiju
Institution/Community
Psihologija / Psychology
TY  - JOUR
AU  - Bjekić, Jovana
AU  - Colić, Marija V.
AU  - Živanović, Marko
AU  - Milanović, Slađan D.
AU  - Filipović, Saša R.
PY  - 2019
UR  - http://reff.f.bg.ac.rs/handle/123456789/2852
AB  - Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Forty-two healthy adults participated in two sham-controlled cross-over experiments. Anodal electrode (20 min, 1.5 mA) was placed over P3 in Experiment 1 and over P4 in Experiment 2. During tDCS participants played a simple computer game. After each stimulation session, participants completed parallel forms of an associative memory task (Experiment 1: face-word memory; Experiment 2: object-location memory) and a control task (verbal fluency). In both experiments, associative memory was improved after anodal stimulation compared to sham stimulation, while no differences were observed in the control task. Additionally, memory performance was higher in the second than in the first trial, but the increase in performance between the two trials did not differ between stimulation conditions. It can be concluded that a single-session anodal tDCS over posterior parietal cortex can improve associative memory performance. The specificity, robustness, and reproducibility of the effect suggest that PPC is a promising target for brain stimulation aiming to enhance memory functions.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Neurobiology of Learning and Memory
T1  - Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory
EP  - 120
SP  - 114
VL  - 157
DO  - 10.1016/j.nlm.2018.12.007
ER  - 
@article{
author = "Bjekić, Jovana and Colić, Marija V. and Živanović, Marko and Milanović, Slađan D. and Filipović, Saša R.",
year = "2019",
abstract = "Associative memory plays a key role in everyday functioning, but it declines with normal ageing as well as due to various pathological states and conditions, thus impairing quality of life. Associative memory enhancement via neurostimulation over frontal areas resulted in limited success, while posterior stimulation sites seemed to be more promising. We hypothesized that anodal transcranial direct current stimulation (tDCS) of parietal areas would lead to higher performance in associative memory due to high connectivity between posterior parietal cortex (PPC) and hippocampus. Forty-two healthy adults participated in two sham-controlled cross-over experiments. Anodal electrode (20 min, 1.5 mA) was placed over P3 in Experiment 1 and over P4 in Experiment 2. During tDCS participants played a simple computer game. After each stimulation session, participants completed parallel forms of an associative memory task (Experiment 1: face-word memory; Experiment 2: object-location memory) and a control task (verbal fluency). In both experiments, associative memory was improved after anodal stimulation compared to sham stimulation, while no differences were observed in the control task. Additionally, memory performance was higher in the second than in the first trial, but the increase in performance between the two trials did not differ between stimulation conditions. It can be concluded that a single-session anodal tDCS over posterior parietal cortex can improve associative memory performance. The specificity, robustness, and reproducibility of the effect suggest that PPC is a promising target for brain stimulation aiming to enhance memory functions.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Neurobiology of Learning and Memory",
title = "Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory",
pages = "120-114",
volume = "157",
doi = "10.1016/j.nlm.2018.12.007"
}
Bjekić, J., Colić, M. V., Živanović, M., Milanović, S. D.,& Filipović, S. R.. (2019). Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory. in Neurobiology of Learning and Memory
Academic Press Inc Elsevier Science, San Diego., 157, 114-120.
https://doi.org/10.1016/j.nlm.2018.12.007
Bjekić J, Colić MV, Živanović M, Milanović SD, Filipović SR. Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory. in Neurobiology of Learning and Memory. 2019;157:114-120.
doi:10.1016/j.nlm.2018.12.007 .
Bjekić, Jovana, Colić, Marija V., Živanović, Marko, Milanović, Slađan D., Filipović, Saša R., "Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory" in Neurobiology of Learning and Memory, 157 (2019):114-120,
https://doi.org/10.1016/j.nlm.2018.12.007 . .

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