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dc.creatorBurger, Joachim
dc.creatorLink, Vivian
dc.creatorBlocher, Jens
dc.creatorSchulz, Anna
dc.creatorSell, Christian
dc.creatorPochon, Zoe
dc.creatorDiekmann, Yoan
dc.creatorŽegarac, Aleksandra
dc.creatorHofmanova, Zuzana
dc.creatorWinkelbach, Laura
dc.creatorReyna-Blanco, Carlos S.
dc.creatorBieker, Vanessa
dc.creatorOrschiedt, Jorg
dc.creatorBrinker, Ute
dc.creatorScheu, Amelie
dc.creatorLeuenberger, Christoph
dc.creatorBertino, Thomas S.
dc.creatorBollongino, Ruth
dc.creatorLidke, Gundula
dc.creatorStefanović, Sofija
dc.creatorJantzen, Detlef
dc.creatorKaiser, Elke
dc.creatorTerberger, Thomas
dc.creatorThomas, Mark G.
dc.creatorVeeramah, Krishna R.
dc.creatorWegmann, Daniel
dc.date.accessioned2021-10-12T13:21:09Z
dc.date.available2021-10-12T13:21:09Z
dc.date.issued2020
dc.identifier.issn0960-9822
dc.identifier.urihttp://reff.f.bg.ac.rs/handle/123456789/3150
dc.description.abstractLactase persistence (LP), the continued expression of lactase into adulthood, is the most strongly selected single gene trait over the last 10,000 years in multiple human populations. It has been posited that the primary allele causing LP among Eurasians, rs4988235-A [1], only rose to appreciable frequencies during the Bronze and Iron Ages [2, 3], long after humans started consuming milk from domesticated animals. This rapid rise has been attributed to an influx of people from the Pontic-Caspian steppe that began around 5,000 years ago [4, 5]. We investigate the spatiotemporal spread of LP through an analysis of 14 warriors from the Tollense Bronze Age battlefield in northern Germany (similar to 3,200 before present, BP), the oldest large-scale conflict site north of the Alps. Genetic data indicate that these individuals represent a single unstructured Central/Northern European population. We complemented these data with genotypes of 18 individuals from the Bronze Age site Mokrin in Serbia (similar to 4,100 to similar to 3,700 BP) and 37 individuals from Eastern Europe and the Pontic-Caspian Steppe region, predating both Bronze Age sites (similar to 5,980 to similar to 3,980BP). We infer low LP in all three regions, i.e., in northern Germany and South-eastern and Eastern Europe, suggesting that the surge of rs4988235 in Central and Northern Europe was unlikely caused by Steppe expansions. We estimate a selection coefficient of 0.06 and conclude that the selection was ongoing in various parts of Europe over the last 3,000 years.en
dc.publisherCell Press, Cambridge
dc.relationGerman Research Foundation (DFG) [BO4119/1-1]
dc.relationSwiss National Science FoundationSwiss National Science Foundation (SNSF) European Commission [31003A_173062]
dc.rightsrestrictedAccess
dc.sourceCurrent Biology
dc.titleLow Prevalence of Lactase Persistence in Bronze Age Europe Indicates Ongoing Strong Selection over the Last 3,000 Yearsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage+
dc.citation.issue21
dc.citation.other30(21): 4307-+
dc.citation.rankaM21
dc.citation.spage4307
dc.citation.volume30
dc.identifier.doi10.1016/j.cub.2020.08.033
dc.identifier.pmid32888485
dc.identifier.scopus2-s2.0-85091233471
dc.identifier.wos000585930500038
dc.type.versionpublishedVersion


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